MEDLINE Abstract

processing....

Download This

View This Abstract Online

Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.

J Biol Chem. 1995; 270(26):15455-8 (ISSN: 0021-9258)

Usdin TB; Gruber C; Bonner TI

We have identified a G-protein-coupled receptor specifically activated by parathyroid hormone, which we refer to as the PTH2 receptor. Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP, hypercalcemia of malignancy factor) activate a previously identified PTH/PTHrP receptor, which has a widespread tissue distribution. The PTH2 receptor is much more selective in ligand recognition and appears to have a more specific tissue distribution. It is activated by PTH and not by PTHrP and is particularly abundant in the brain and pancreas.

Major Subject Heading(s)	Minor Subject Heading(s)	CAS Registry / EC Numbers
	Amino Acid Sequence Base Sequence Humans Molecular Sequence Data Parathyroid Hormone [pharmacology] Parathyroid Hormone-Related Protein Proteins [pharmacology] RNA, Messenger [analysis] Receptor, Parathyroid Hormone, Type 1 Receptors, Parathyroid Hormone [analysis] [chemistry] [genetics]	0 (PTHLH protein, human) 0 (Parathyroid Hormone) 0 (Parathyroid Hormone-Related Protein) 0 (Proteins) 0 (RNA, Messenger) 0 (Receptor, Parathyroid Hormone, Type 1) 0 (Receptors, Parathyroid Hormone)

PreMedline Identifier: 7797535

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

processing....